Lions vs. Colts odds, line, start time: 2024 NFL picks, Week 12 predictions from proven model

The Detroit Lions (9-1) can take another step toward earning the top seed in the NFC when they face the Indianapolis Colts (5-6) on Sunday afternoon. Detroit has won eight straight games and is coming off a 52-6 win over Jacksonville, marking the largest winning margin in franchise history. The Lions are one game ahead of Philadelphia and Minnesota in the loss column atop the conference standings. Indianapolis is one game back of Denver for the final AFC wild-card spot, and it is two games behind Houston in the AFC South. 

Kickoff is set for 1 p.m. ET on Sunday at Lucas Oil Stadium. The Lions are favored by 7.5 points in the latest Colts vs. Lions odds, while the over/under is 50.5 points. The Lions are -392 money-line favorites (risk $392 to risk $100), while the Colts are +307 underdogs (risk $100 to win $307). Before entering any Lions vs. Colts picks, you’ll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 12 of the 2024 NFL season on an incredible 20-8 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 200-136 roll on top-rated NFL picks that dates back to the 2017 season and a 54-29 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.

The model has set its sights on Detroit vs. Indianapolis. You can head to SportsLine to see its picks. Here are several NFL betting lines for the game:

• Colts vs. Lions spread: Lions -7.5
• Colts vs. Lions over/under: 50.5 points
• Colts vs. Lions money line: Lions -392, Colts +307
• Colts vs. Lions picks: See picks here
• Colts vs. Lions streaming: FuboTV (Try for free)

Why the Colts can cover

Indianapolis lost three straight games from the end of October to the middle of November, but it snapped that skid with a 28-27 win over the Jets last week. The Colts desperately needed that win to stay in contention for an AFC wild-card spot, especially since they have to travel to Denver next month. Second-year quarterback Anthony Richardson completed 20 of 30 passes for 272 yards and a touchdown in the win over the Jets, and his second scoring run was the game-winning play. 

The Colts are 3-2 in their five home games this season, picking up wins over the Bears, Steelers and Dolphins. One of those two losses came in a 29-27 final against Houston, so the Colts are not used to losing games with margin at home. They have covered the spread in seven of their last nine games, including four of their last five home games. See which team to pick here. 

Why the Lions can cover

Detroit is the hottest team in the NFL right now, extending its winning streak to eight games with a 52-6 blowout against Jacksonville last week. The NFC-leading Lions have won nine of their first 10 games in a season for the first time since 1934. Their 46-point winning margin was the largest in franchise history, setting a team record for total yards (645) as well. 

Quarterback Jared Goff completed 24 of 29 passes for 412 yards, four touchdowns and zero interceptions before getting to sit out in the fourth quarter. Running back David Montgomery had 75 rushing yards and two touchdowns, while wide receiver Amon-Ra St. Brown had 11 receptions for 161 yards and two scores. The Lions have covered the spread in seven of their last eight games, and the Colts are 3-11 in their last 14 games as underdogs. See which team to pick here. 

How to make Lions vs. Colts picks

The model has simulated Colts vs. Lions 10,000 times and the results are in. The model is leaning Over, and it’s also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Indianapolis vs. Detroit on Sunday, and which side of the spread hits well over 50% of the time? Visit SportsLine right now to see which side of the Colts vs. Lions spread you should be all over, all from the model on a 200-136 roll on its top-rated NFL picks, and find out.